Bookcover of Inborn Error of Phenylalanine Metabolism:
Booktitle:

Inborn Error of Phenylalanine Metabolism:

Easy Methods of Detection of PKU using Plant Enzymatic Assay and Rat Model

LAP LAMBERT Academic Publishing (2014-12-30 )

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ISBN-13:

978-3-659-40185-5

ISBN-10:
3659401854
EAN:
9783659401855
Book language:
English
Blurb/Shorttext:
This book encompasses the technical details of phenylalanine ammonia -lyase (PAL) assay which serves as a quick easy method for detecting phenylketonuria (PKU), an inborn error of phenylalanine metabolism in neonates. The protocol of extraction, immobilization of PAL from a higher plant (Cucumis sativus L.) and its application in assessing the activity of a hepatic key enzyme of the malady, phenylalanine hydroxylase (PAH) in the animal experimental system (Wistar Rat Model) are explained. The principle of population screening is to identify persons with biologic markers of the disease. A simple test is imperative to identify the biomarkers of the disease. The novel PAL assays developed in the present research are valid on the pCPA-administered rat model system which can be extended to human phenylketonurics. The book would be immensely useful for clinical biochemists, geneticists and enzymologists.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Ebenezer Wilson
Number of pages:
116
Published on:
2014-12-30
Stock:
Available
Category:
Biochemistry, biophysics
Price:
54.90 €
Keywords:
Metabolism, clinical, Phenylketonuria, Inborn, biochemists, PKU, enzymologists, Plant Enzymatic Assay, detection, ​detection

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