Bookcover of Gene Regulation by Numbers
Booktitle:

Gene Regulation by Numbers

Steady-State and Equilibrium Binding Applied to Gene Regulation Systems

Südwestdeutscher Verlag für Hochschulschriften (2012-04-20 )

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ISBN-13:

978-3-8381-3288-4

ISBN-10:
3838132882
EAN:
9783838132884
Book language:
English
Blurb/Shorttext:
This thesis is composed of three parts that are presented in a hierarchical order reflecting increasing organization level of the studied system. Gene regulation was studied at the single gene level first, extended to interacting transcriptional units and finally to its role within small regulatory networks. Our approach consists of an iterative experimental-based mathematical modeling based on promoter libraries with synthetic binding site sequences of variable affinities for selected transcriptional activators. We used such libraries to perform in vivo experiments using the yeast Saccharomyces cerevisiae in order to improve our theoretical models. The main goal of the work is the determination of gene system’s intrinsic properties like cooperativity coefficients and binding affinities of transcription factors to DNA regulatory sequences.
Publishing house:
Südwestdeutscher Verlag für Hochschulschriften
Website:
https://www.svh-verlag.de
By (author) :
Buetti-Dinh Antoine
Number of pages:
228
Published on:
2012-04-20
Stock:
Available
Category:
General Natural Sciences
Price:
89.90 €
Keywords:
gene regulation, mathematical modeling

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