Bookcover of Development of a novel hydrogel for skin regeneration
Booktitle:

Development of a novel hydrogel for skin regeneration

LAP LAMBERT Academic Publishing (2014-10-16 )

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ISBN-13:

978-3-659-59717-6

ISBN-10:
3659597171
EAN:
9783659597176
Book language:
English
Blurb/Shorttext:
Skin lesions are traumatic events that lead to increased fluid loss, infections, scars formation and the appearance of immunocompromised regions. The loss of skin integrity can result in significant physiological imbalances and disability or even death. So far, different wound dressings have been developed. Among them, hydrogels are the most applied. Herein, a thermoresponsive hydrogel was produced using chitosan and agarose formed at body temperature (37°C), in order to verify their applicability in the treatment of wounds. Hydrogel bactericidal activity, biocompatibility, morphology, porosity and wettability were characterized by confocal microscopy, MTS assay and SEM. The attained results revealed that hydrogel has a pore size (90–400 µm) compatible with cellular internalization and proliferation. A bactericidal activity was observed for hydrogels containing more than 188 µg/mL of chitosan. The results obtained demonstrated that this 3D network has the suitable properties for improving the healing process of cutaneous wounds.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Sónia Miguel, Maximiano Ribeiro, Ilídio Correia
Number of pages:
88
Published on:
2014-10-16
Stock:
Available
Category:
Biology
Price:
39.90 €
Keywords:
biocompatibility, in vitro studies, wound healing, Cell internalization., Antimicrobial activity

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