Bookcover of Development and Evaluation of Proliposomes-Based Drug Delivery Systems
Booktitle:

Development and Evaluation of Proliposomes-Based Drug Delivery Systems

Proliposomes-Based Drug Delivery Systems

LAP LAMBERT Academic Publishing (2012-06-18 )

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ISBN-13:

978-3-659-16098-1

ISBN-10:
3659160989
EAN:
9783659160981
Book language:
English
Blurb/Shorttext:
The present investigation aimed at formulation, and evaluation of vesicular drug carrier system liquid crystalline proliposomes for transdermal delivery of antifungal agent, griseofulvin. Liquid crystalline proliposomal gel (LCPG) formulations of griseofulvin were prepared, and characterized for vesicles shape, size, entrapment efficiency, and drug permeation across pig ear skin. The effects of different formulation variables (type of alcohol, type and concentration of surfactant) on transdermal permeability profile were assessed. The optimized LCPG formulation showed enhanced In Vitro skin permeation flux of 10.705 ± 0.052 µg/cm2/hr as compared to 0.028 ± 0.02 µg/cm2/hr for plain drug solution in water. Results indicated that the optimized proliposomal formulation of griseofulvin had better skin permeation potential than plain drug solution in water.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Sandeep Gupta, Dheeraj Ahirwar, Aditya Nath Pandey
Number of pages:
64
Published on:
2012-06-18
Stock:
Available
Category:
Pharmacy
Price:
49.00 €
Keywords:
Transdermal delivery, griseofulvin (GF), liquid crystalline proliposomes, liquid crystalline proliposomal gel (LCPG)

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