Bookcover of Cyclophilin A as an apoptotic effector
Booktitle:

Cyclophilin A as an apoptotic effector

A cell-based study

AV Akademikerverlag (2012-06-11 )

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ISBN-13:

978-3-639-42487-4

ISBN-10:
3639424875
EAN:
9783639424874
Book language:
English
Blurb/Shorttext:
Hepatocellular carcinoma is one of the leading cancer-related causes of death. So far, no life-saving therapy is available, due to a widespread resistance of cancer cells to apoptosis, impeding effectual treatment with anticancer drugs. Thus, an improved understanding of apoptosis and other cell death pathways is fundamental to develop new drugs to bypass tumor drug resistance. This study characterizes caspase-independent apoptosis induced by the death receptor-ligand CD95L in HepG2 cells. Furthermore the role of cyclophilin A (CypA) and apoptosis inducing factor (AIF) in apoptotic cell death are studied. An essential role of CypA in apoptotic cell death is demonstrated. On the one hand this protein is essential for the activation of at least effector caspases and on the other hand, the outcome of cell death is modulated both upon overexpression and knockdown of CypA.
Publishing house:
AV Akademikerverlag
Website:
http://www.akademikerverlag.de/
By (author) :
Dominik Pöltl
Number of pages:
120
Published on:
2012-06-11
Stock:
Available
Category:
Biochemistry, biophysics
Price:
32.95 €
Keywords:
cancer, apoptosis, caspases, cell death, Cyclophilin A, PPIA, Hepatocellular Carcinoma

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