Bookcover of Comparative Analysis of Contacts Between Crystal Lattice & Oligo Interface
Booktitle:

Comparative Analysis of Contacts Between Crystal Lattice & Oligo Interface

LAP LAMBERT Academic Publishing (2016-07-26 )

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ISBN-13:

978-3-659-91497-3

ISBN-10:
3659914975
EAN:
9783659914973
Book language:
English
Blurb/Shorttext:
G proteins are molecular amplifiers. GTPases are a large family of enzymes that can bind and hydrolyze GTP. The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases. Protein crystal contacts are weak and generally form only under conditions designed to limit protein solubility and maximize protein-2 interactions. However, they do form with a kind of specificity, at least in the sense that only certain contacts are repeated within each unit cell of any particular crystal packing arrangement. For oligomeric proteins, amino acids at the subunit interfaces have been selected in order to maintain affinity and specificity properties. Many proteins contain highly flexible or even completely unfolded fragments that dramatically interfere with crystallization conditions. These conditions are the crystal lattice and Oligomeric interface or proteins that allow the residues to bind in such a specific way by which the crystallization of GTPase is fast. This book therefore, should be helpful for better understanding the crystallograpgy of proteins for biologists etc.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Ashish Kumar Jaiswal
Number of pages:
52
Published on:
2016-07-26
Stock:
Available
Category:
Biochemistry, biophysics
Price:
28.90 €
Keywords:
bioinformatics, G proteins, GTPase, Insilico, PDB, Crystal lattice, Oligimeric interface, Protein crystals

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