Bookcover of Anti-tumour Properties of Iraqi Propolis: in vitro and in vivo
Booktitle:

Anti-tumour Properties of Iraqi Propolis: in vitro and in vivo

Investigation of anti-tumour effects of Iraqi propolis in human cancer cell lines in vitro and in nude mice xenografts

LAP LAMBERT Academic Publishing (2012-01-03 )

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ISBN-13:

978-3-8465-5455-5

ISBN-10:
3846554553
EAN:
9783846554555
Book language:
English
Blurb/Shorttext:
Healing properties of propolis are known in folk medicine from antiquity; however, recently, the interest in propolis as a potential natural product is increasing because of its broad spectrum of biological properties. It is an anti-flammatory agent, an immunostimulant, anti-oxidant, anti-microbial, and it is also an anti-tumour and a carcinostatic agent. This study was undertaken to characterize the chemical compounds, and antioxidant and anti-tumour potentials of propolis samples collected from five different geographical locations in Iraq using in vitro and in vivo studies. Thirty-eight different compounds were identified, and clerodane diterpenoids were identified for first time in temperate zone. All propolis samples exhibited strong free radical scavenging activity. The in vitro evaluations by growth inhibition, clonogenicity and flow cytometric assays showed that propolis has cytotoxic effects on two human cell lines. The in vivo potentials were also recorded on the growth of HCT-116 xenografts in a nude mouse model. This study provides the rationale to investigate the potential beneficial effect of propolis in the diet of patients receiving anti-cancer therapies.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Ghassan Sulaiman, Khulood Al Sammarae, Ali Ad'hiah
Number of pages:
232
Published on:
2012-01-03
Stock:
Available
Category:
Monographies
Price:
79.00 €
Keywords:
Iraqi propolis, Anti-tumour, Chemical characterization

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