Bookcover of Anti-Human Galanin Receptor Antibodies
Booktitle:

Anti-Human Galanin Receptor Antibodies

An Evaluation in Normal and Pathologic Tissues

AV Akademikerverlag (2013-03-24 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-639-45603-5

ISBN-10:
3639456033
EAN:
9783639456035
Book language:
English
Blurb/Shorttext:
The neuropeptide galanin is involved in the regulation of several physiological processes, which are mediated via three different G-protein-coupled receptors (GPCRs). The galanin receptors show distinct but overlapping expression in the central nervous system and in the periphery. GPCRs have been described as major drug targets for various human diseases. Therefore, the determination of the cellular and subcellular localization of galanin receptors is of high interest. Antibodies are a valuable tool to study the distribution of receptors of interest. Even though there are several antibodies raised against the different galanin receptor subtypes commercially available, it has been demonstrated that lack of selectivity appears to be the rule rather than the exception for antibodies against these GPCRs. Therefore, the specificity of several commercially available antibodies to human galanin receptors was evaluated in immunoblotting and immunohistochemistry. One out of two anti-GalR1 antibodies, one out of two anti-GalR2 antibodies and one out of three tested anti-GalR3 antibodies showed specific staining in Western blot analysis and immunohistochemistry. Using these antibodies it was possible for the first time and in detail to illustrate the cellular expression and localization of the three galanin receptor subtypes in numerous normal and pathologic human tissues.
Publishing house:
AV Akademikerverlag
Website:
http://www.akademikerverlag.de/
By (author) :
Bernhard Brodowicz
Number of pages:
112
Published on:
2013-03-24
Stock:
Available
Category:
Other
Price:
32.95 €
Keywords:
molecular biology, Validation, Histology, antibody, Human Biology, GPCRs, Galanin, Receptor Biochemistry, Immunohistochemistry, neurobiology

Books loader

Adyen::diners Adyen::jcb Adyen::discover Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Adyen::paypal Paypal Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING