Couverture de Neuronal calcium regulation and cell stress in Malignant Hyperthermia
Titre du livre:

Neuronal calcium regulation and cell stress in Malignant Hyperthermia

LAP LAMBERT Academic Publishing (14-03-2016 )

Books loader

Omni badge éligible au bon d'achat
ISBN-13:

978-3-659-81748-9

ISBN-10:
3659817481
EAN:
9783659817489
Langue du livre:
Anglais
texte du rabat:
Calcium ions (Ca2+) are essential signaling molecules and must be carefully regulated to preserve specificity in function. One indispensible Ca2+ signaling protein is the ryanodine receptor (RyR) calcium release channel. RyR1 is essential for muscle contraction, and RyR1mutations can lead to severe muscle disorders such as malignant hyperthermia (MH). Recently, a mouse model of human MH (Y522S-RyR1) has been developed. In skeletal muscle, Y522S-RyR1 exhibits an increased sensitivity to activation resulting in Ca2+ leak, mitochondrial disorganization, and cellular stress. Although RyR1 expression is limited in the brain, the cerebellum may be particularly vulnerable to this disease because RyR1 is highly expressed in Purkinje neurons. In this study, Y522S-RyR1 in Purkinje cells exhibits a lower threshold for activation, but does not cause severe cellular stress and damage. Future investigation of compensatory mechanisms for increased Ca2+ release in Purkinje cells could be of therapeutic value for many neurological and muscular disorders.
Maison d'édition:
LAP LAMBERT Academic Publishing
Site Web:
https://www.lap-publishing.com/
de (auteur) :
Jason Santiago
Numéro de pages:
68
Publié le:
14-03-2016
Stock:
Disponible
Catégorie:
Sciences naturelles générale
Prix:
373.46 HK$
Mots-clés:
Calcium, cerebellum, Malignant Hyperthermia, Purkinje Cell, oxidative stress

Books loader

Lettre d'information

Adyen::diners Adyen::jcb Adyen::discover Adyen::cup Adyen::unionpay Adyen::paypal Paypal CryptoWallet

  0 produits dans le panier
Modifier le contenu du panier
Loading frontend
LOADING