TOR and GSK3 in the ciliate Paramecium tetraurelia的封面
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TOR and GSK3 in the ciliate Paramecium tetraurelia

Target of Rapamycin and Glycogen Synthase Kinase 3 pathway orthologs and their regulation of ciliary length/assembly

LAP LAMBERT Academic Publishing (2012-05-30 )

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ISBN-13:

978-3-659-12835-6

ISBN-10:
365912835X
EAN:
9783659128356
书籍语言:
英文
作品简介:
Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag A/B, Rag C/D, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and /or assembly in P. tetraurelia. We also hypothesize that these regulations are TOR dependent.
出版社 :
LAP LAMBERT Academic Publishing
网址:
https://www.lap-publishing.com/
由(作者):
Tatyana Svinkina
页码 :
340
发表日期:
2012-05-30
现货:
备有现货
类别:
生物学
价格:
79.00 €
关键词:
Cilia, mTOR, GSK3, Paramecium tetraurelia, ciliary length

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