Matrix and Porous Osmotic Pump Tablets - A Comparative Study的封面
书籍主题:

Matrix and Porous Osmotic Pump Tablets - A Comparative Study

Formulation Development and Optimization

LAP LAMBERT Academic Publishing (2012-06-11 )

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ISBN-13:

978-3-659-14277-2

ISBN-10:
3659142778
EAN:
9783659142772
书籍语言:
英文
作品简介:
Over the last few years the controlled drug delivery becomes a predominant method for treatment for most of the diseases. In this book the importance of porous osmotic pump tablets over the matrix tablets for controlled delivery of Diclofenac sodium (DS) were elucidated. The solubility of DS is highly pH dependent. The matrix tablets (MT) were prepared by direct compression method. The porous osmotic pump tablets (CPOP) were designed using D-Optimal design. All formulations were evaluated for various physicochemical parameters and in vitro drug release kinetic studies were determined and compared. ANOVA studies in drug release of all the formulations were determined. Numerical optimization technique was applied to determine the best formulation. The most satisfactory formulations in MT and CPOP were studied for the influence of pH and agitation intensity on release of drug. The membrane morphology of the CPOP was studied using scanning electron microscopy (SEM). The porous osmotic pump tablets provide prolonged, controlled, and gastrointestinal environment-independent drug release than matrix tablets.
出版社 :
LAP LAMBERT Academic Publishing
网址:
https://www.lap-publishing.com/
由(作者):
Sudeesh Edavalath
页码 :
136
发表日期:
2012-06-11
现货:
备有现货
类别:
药学
价格:
59.00 €
关键词:
controlled release, diclofenac sodium, Matrix Tablets, Osmotic pump tablets

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