Characterization of two metallocarboxypeptidases of M14D subfamily的封面
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Characterization of two metallocarboxypeptidases of M14D subfamily

LAP LAMBERT Academic Publishing (2015-03-10 )

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ISBN-13:

978-3-659-68560-6

ISBN-10:
3659685607
EAN:
9783659685606
书籍语言:
英文
作品简介:
M14D subfamily or cytosolic carboxypeptidases (CCPs) are distributed throughout the phylogenetic tree. CCPs common domains architecture consists in the amino-terminal and the carboxypeptidase domains, both conserved in the subfamily. Eukaryotic CCPs process the C-terminal posttranslational modifications of tubulins and possibly of other proteins. Its cellular function could be primarily related to cilia and basal bodies. On the other hand, prokaryotic CCPs are poorly characterized from the biochemical and functional point of view. The present work aimed to provide more information on key structural and functional features of M14D subfamily using the CCP from Pseudomonas aeruginosa (PaCCP) and the human CCP6 (hCCP6) as models. The crystal 3D structure of recombinant PaCCP was solved and provides a first detailed structural insight into mammalian CCPs. The functional processes involving PaCCP and hCCP6 were explore using biochemical, microbiological and proteomics methods.
出版社 :
LAP LAMBERT Academic Publishing
网址:
https://www.lap-publishing.com/
由(作者):
Anabel Otero Bilbao
页码 :
180
发表日期:
2015-03-10
现货:
备有现货
类别:
生物化学 ,生物物理学
价格:
71.90 €
关键词:
Tubulin, metallocarboxypeptidases, M14D subfamily, pseudomonas

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